Thrombospondin-1 expression and modulation of Wnt and hippo signaling pathways during the early phase of Trypanosoma cruzi infection of heart endothelial cells.

When TSP1 KO MHEC (in the absence of TSP1) were challenged with the parasite, we observed a significant decrease in the levels of p-GSK-3β (Ser9) at 1 h (0.57±0.12; P< 0.01) followed by an increasing trend from 2- to 6 h that was maximum at 2 h (2.99±0.24; P< 0.001) compared with control ( Fig 2B ).

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