Mucosal immunity to poliovirus.

A highly significant inverse correlation was found between the enteric mucosal responses and the amount of virus shed after challenge 16 – 18 .

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While well-immunized IPV populations have controlled poliomyelitis and, for the most part poliovirus transmission, evidence of increased virus shedding in IPV-immunized older children following oral exposure to live virus may be significant in terms of potential enhancement of silent wild-type or VDPV circulation, particularly in geographic areas of low vaccine coverage.

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