Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar.

PLoS Negl Trop Dis · 2021 · PMC8735616 · PMID 34936652

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may be significantno p-value reported

If TP0380 mutation is indeed responsible for the elevated rate of mutation seen within the Nichols A subclade, the implications for vaccine design may be significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.