Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism.

Elife · 2021 · PMC8735863 · PMID 34939929

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Both treatments resulted in highly significant changes in the transcriptome and gene set enrichment analysis (GSEA) ( Subramanian et al., 2005 ) identified robust activation of an amino acid deprivation response, in line with the decrease in aspartate and proline we observed.

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