Treatment-Specific Hippocampal Subfield Volume Changes With Antidepressant Medication or Cognitive-Behavior Therapy in Treatment-Naive Depression.

The other notable results from this study are: (1) various hippocampal subregion volumes are smaller in patients with MDD compared to healthy controls, which is consistent with previous findings ( 6 ); (2) six hippocampal subregion volumes demonstrated decreases after 12 weeks of treatment regardless of treatment or outcome, particularly the highly significant finding of left HATA volume reduction; (3) larger baseline right fimbria and HATA volumes in the CBT-treated patients were positively associated with clinical improvement.

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