Device-Based Enrichment of Knee Joint Synovial Cells to Drive MSC Chondrogenesis Without Prior Culture Expansion In Vitro: A Step Closer to 1-Stage Orthopaedic Procedures.

Am J Sports Med · 2022 · PMC8739599 · PMID 34779670

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.2500

boldest claim

The sentences

narrowly failed significanceP = .06so close (0.05 < p ≤ 0.1)

Although SOX9 and ACAN were significantly increased with CCM ( P = .0043; P = .0006), AUT-fPC ( P = .04 and P = .0033), and ALL-fPC ( P = .005 and P = .0035) as compared with the negative control, a significant increase in COL2A1 was observed with CCM ( P = .0016) and ALL-fPC ( P = .014) but narrowly failed significance for AUT-fPC ( P = .06) ( Figure 2C ).

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an increasing trendP = .25not close (p > 0.1)

An increasing trend was observed with Sm-MSCs for chondrogenic markers SOX9 (3.8-fold; P = .25), ACAN (2.3-fold; P = .25), COMP (2.6-fold; P = .25), and COL2A1 (19-fold; P = .25) ( Figure 2F ) as compared with SF-MSCs, as well as notable increases in the expression of SFRP4 (584-fold) and GDF5 (3.5-fold), which are both highly specific for synovial-origin MSCs 4 , 24 , 48 ( Appendix Figure A3 , available online).

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