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Assessment of factors associated with PSA level in prostate cancer cases and controls from three geographical regions.

Sci Rep · 2022 · PMC8742081 · PMID 34997089

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an increasing trendno p-value reported
It is a possibility that the AKR1C3 rs12529 GG genotype carriers among NZ cases with an increasing trend of age dependent AKR1C3 activity could lead to increased ROS production as they age if exposed to more reactive O-quinone formation due to ever-smoking habits.

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