Clinical evaluation of large volume subcutaneous injection tissue effects, pain, and acceptability in healthy adults.

Several prior published studies show a limited impact of injection rate without clinically significant differences for subject VAS pain perception and others an observed trend toward lower VAS scores at slower rates. 17 , 21 , 30 , 35 , 37 , 41 , 42 LVSC administrations up to 600 ml have previously been well‐tolerated when co‐delivered with permeation enhancers, such as recombinant human hyaluronidase. 1 , 29 The current study used a s

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