miR-199a Downregulation as a Driver of the NOX4/HIF-1α/VEGF-A Pathway in Thyroid and Orbital Adipose Tissues from Graves' Patients.

A significant reduction of circulating miR-199a-3p and a decreasing trend of miR-199a-5p were observed in the plasma of GD patients ( Supplemental Figure S4 ). 2.7.

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In GO orbital adipose tissue, an increasing trend was observed for STAT3 phosphorylation on Tyr705, while no modification was detected for total STAT3 protein expression ( Figure 7 D–F). 3.

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