Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX.

There was a slight trend that the compounds bearing less flexible substituents, 5a and 5b or 9a and 9b , often had higher affinity than 5c , 5d , 5f , and 9c , 9d , 9f .

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