The Prognostic Value of ¹⁸F-FDG PET Imaging at Staging in Patients with Malignant Pleural Mesothelioma: A Literature Review.

[ 44 ], PET uptake parameters were not or borderline significant at multivariable analysis, likely due to the limited number of patients; moreover, previous pleurodesis and use of different PET scanners were additionally reported as possible factors limiting the prognostic analysis by Billè et al.

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The remaining 8/17 studies considered both SUV-based and volumetric parameters (MTV and TLG) [ 29 , 34 , 35 , 37 , 45 , 46 , 47 , 50 ]: volumetric parameters showed a better prognostic value than SUV measure in 5/8 cases [ 34 , 35 , 37 , 47 , 50 ], with SUVmax of borderline significance and at univariate analysis only (in the studies by Nowak et al. and Klabatsa et al.), or significant at univariate analysis only (as reported by Doi et al.), or with totally no prognostic prediction power (as found by Lee et al. and Pavic et al.); SUVmax remained the only significant prognostic factor at multivariate analysis (if histology variable was excluded) in one study, when compared to MTV and TLG [ 46 ]; all PET parameters were significantly associated with prognosis in the remaining two studies [ 29 , 45 ].

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