Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent.

Arch Toxicol · 2022 · PMC8748370 · PMID 34669010

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a decreasing trendno p-value reported

an increasing trendno p-value reported

Thus as the dose increases, the AUC RID from orally administered riddelliine N -oxide shows a decreasing trend, while orally administered riddelliine generates AUC RID with an increasing trend.

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