Prefrontal cortical plasticity during learning of cognitive tasks.

Comparison of mean firing rates of responsive single neurons for the best location of each neuron in each training phase, after subtracting baseline activity, revealed a highly significant difference between stages (Fig. 3b ; 1-way ANOVA test, F 3,531 = 72.4, p = 2.87 × 10 −39 for the cue period, F 3,531 = 21.93, p = 2.12 × 10 −13 for the first delay period).

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