This assumption was strongly supported by clinical data from large-scale gene expression data sets (TCGA database), which revealed a highly significant correlation between FOXO3 and ITGA5 expression in ERα+, but not in ERα−, BC patients ( Figure 3 i).
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FoxO3a Inhibits Tamoxifen-Resistant Breast Cancer Progression by Inducing Integrin α5 Expression.
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