Rare sugars and their health effects in humans: a systematic review and narrative synthesis of the evidence from human trials.

Ingestion of 10 g of allulose together with a 75 g OGTT resulted in both a lower plasma glucose iAUC and plasma glucose absolute mean compared with a control of water, while a dose of 5 g of allulose had a borderline significant effect. 40 A systematic review and meta-analysis of acute feeding trials in people with and without diabetes showed that a small dose of allulose (<30 g) reduced the postprandial iAUC glucose response to the oral glucose load by 10%, while there was an indication of a nonsignificant improvement in iAUC insulin. 62 These randomized controlled trials demonstrate that small doses of allulose can lead to modest improvement in the postprandial glycemic response to co-ingested carbohydrate.

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