Quantification of human plasma metalloproteins in multiple sclerosis, ischemic stroke and healthy controls reveals an association of haptoglobin-hemoglobin complexes with age.

We also investigated if the Hp-Hb peak correlated with age and indeed observed that only age was close to being statistically significant (p = 0.05) in a linear regression model that included the participant groups and the square root of the Fe-peak areas corresponding to the Hp-Hb complex.

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From a linear regression model with just age regressed on the sqrt(Hp-Hb) values, explicitly ignoring the participant grouping, the sqrt(Hp-Hb) values increase by 0.42 units for every one year increase in age, which was statistically highly significant (p-value 0.005).

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