The results ( Fig 1C ) demonstrated highly significant increases specifically in the levels of α-secretase-generated C83 of 2.44 ± 0.18- and 2.14 ± 0.12-fold, respectively, in lysates prepared from 10 and 20 mM DCA-treated cells (relative to untreated controls).
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The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein.
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