Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease.

The ROI-based linear regression analyses revealed significant negative associations between CSF and the Temp.Comp VBM ( β = −1.15, s.e = 0.44, t (65) = −2.69, p = 0.016) and hippocampus VBM ( β = −0.82, s.e = 0.20, t (65) = –3.99, p < 0.0001) while plasma NFL and VBM in the Temp.Comp and hippocampus ROIs showed a small trend ( t (61) = −1.88, t (61) = −1.81, respectively, p = 0.15).

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