gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.

This analysis demonstrated highly significant enrichment of genes associated with chondrocyte maturation and hypertrophy in the absence of Stat3 (Fig. 6d, f ), while genes such as Sox5/6 that promote proliferation in immature chondrocytes were significantly enriched in control Stat3 fl/fl chondrocytes (Fig. 6e, f ).

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