Altogether, the reported results and the fact that most findings could not be reproduced in independent studies may suggest that the association between HLA antigens and MMD differ between ethnic groups and that the different HLA alleles may not be significant susceptibility factors of MMD rather than genetic markers.
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The sentences
Strong association of the SNP rs599839 [A/G] (OR = 2.17, 95% confidence interval 1.17-4.05; p = 0.01) with the risk allele G located on chromosome 1p13.3 in the 3' UTR region of the PSRC-1 gene and a trend towards significance for three other SNPs (rs8326, rs34208922, rs501120) in or adjacent to the genes ELN and CXCL12 were found [ 86 ].
The association of rs1800471 and tendency toward significance of rs1800470 previously described in the European cohort [ 104 ] could not be replicated in the Japanese cohort.