Barely Significant
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Surveillance, Epidemiology and Impact of EV-A71 Vaccination on Hand, Foot, and Mouth Disease in Nanchang, China, 2010-2019.

Front Microbiol · 2021 · PMC8770912 · PMID 35069515

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an overall trendno p-value reported
During 2015–2019, the proportion of EV-A71 ranged from 14.6 to 25.4%, with an overall trend of decreasing with age, while the proportion of CV-A16 increased with age, but with limited cases older than 10 years.

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an increasing trendno p-value reported
To explore the distribution of the pathogenic spectrum of enteroviruses across age groups, we found that CV-A16 ranged from 13.9 to 33.3% with an increasing trend with age from 2010 to 2014, while EV-A71 accounted for 50.0–55.0% cases in all age groups ( Figure 6B ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.