a decreasing trendp = 0.062
A change in treatment from another ARB to irbesartan resulted in a decrease in hs-CRP (2.80 ± 0.53 versus 2.66 ± 0.50 log(ng mL −1 )) and d-ROMs (338 ± 74 versus 305 ± 62 U.CARR; p < 0.001); there was also a decreasing trend in the proteolytic enzyme released from inflammatory cells, MMP-9 (1.03 ± 0.86 versus 0.62 ± 0.59 mg mL −1 ; p = 0.062) and MPO (1.50 ± 0.70 versus 0.51 ± 0.43 IU mL −1 ; p = 0.057), which plays a role in oxidative and inflammatory processes.