Metabolomic Phenotyping of Gliomas: What Can We Get with Simplified Protocol for Intact Tissue Analysis?

In addition, a comparison of patients with high-grade and low-grade gliomas via LASSO ( Table S10 ) and ANOVA ( Table S12 ) identified 2-aminoadipic acid (2-AAD) ( p < 0.05; [HGG/LGG] ratio 15.89) as a highly significant metabolite differentiating the two groups ( p < 0.05; [HGG/LGG] ratio 11.33).

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Contrary to ANOVA, the metabolites in the chemometric models may not be significant individually, but their corporate constellation nevertheless enables a given sample to be assigned to the appropriate group.

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