Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis.

As a result, the returned prognostic co-mutations were ascertained with three different levels of significance: (1) empirical significance due to imbalanced events; (2) significance with adjusted p -value < 0.05; (3) marginal significance with adjusted p -value falling in [0.05, 0.1].

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The negative correlation between mutational burden and age is marginally significant for Caucasian ( Figure 3 I), significant for Black ( Figure 3 J) and not significant for Asian, which may be due to limited sample size. 2.4.

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