Entropy Effects in Intermolecular Associations of Crown-Ethers and Cyclodextrins with Amino Acids in Aqueous and in Non-Aqueous Media.

It has been observed that complexation reactions involving biologically active molecules and simulating the processes occurring in the living organisms (for example, enzyme–substrate, peptide–DNA, antigen–antibody interactions, etc.) are accompanied by small negative changes of the free energy, despite the fact that changes in the enthalpy may be significant [ 38 , 39 , 40 , 41 ].

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