Capturing SNP Association across the NK Receptor and HLA Gene Regions in Multiple Sclerosis by Targeted Penalised Regression Models.

For example, our elastic net model for the pre-imputed discovery cohort identified SNPs in the NKC and LRC of nominal and borderline significance, while, for the HLA, at least four SNPs that reached above 70% iterations had an associated p-value above 0.4.

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This is particularly surprising, considering the amount of ‘highly significant’ p-value-based SNPs within the HLA loci ( Figure 2 ).

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