Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease.

One reason for this may be co-regulation of multiple genes by the same eQTL, as well as LD between eQTLs with nonzero prediction weights, which may lead to correlated predicted expression between nearby genes and thus multiple correlated TWAS hits per locus 15 , analogous to the situation in a GWAS study where an association signal typically spans a large number of highly significant SNPs in high LD with the causal SNP 26 .

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