highly significantp < 0.05
For each cytokine, the data were evaluated with the help of two-tailed t test (unpaired) on the Prism software v8 (GraphPad Software, La Jolla, CA, USA), with p < 0.05 being designated significant and p < 0.01 being highly significant (ns not significant, * p < 0.05, and ** p < 0.01). 3.