Post-HPV-Vaccination Mast Cell Activation Syndrome: Possible Vaccine-Triggered Escalation of Undiagnosed Pre-Existing Mast Cell Disease?

Although MCs are important elements of the innate and adaptive components of the immune system, and are normally involved in most immune responses, MC disorders have not previously been considered a possibly significant factor in the development of chronic vaccine-related AEs, perhaps because the only disorders of MCs previously recognized were acute allergic-type phenomena and the rare, malignant neoplastic MC disorder of mastocytosis.

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