Successful Dendrimer and Liposome-Based Strategies to Solubilize an Antiproliferative Pyrazole Otherwise Not Clinically Applicable.

Despite the authors success in improving the AMDPC water solubility, considering the very low DL% (DL = 1.28%) obtained in this study, the water solubility achieved for the encapsulated AMDPC was almost insignificant (6.4 × 10 −4 mg/mL), thus making it not feasible or difficult for in vivo administration of the obtained AMDPC formulation without resorting to harmful solvents, such as DMSO.

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