Changes in Oxygen Availability during Glucose-Limited Chemostat Cultivations of <i>Penicillium chrysogenum</i> Lead to Rapid Metabolite, Flux and Productivity Responses.

(b) Sugar phosphates, organic acids, and sugar alcohols Glucose-6-phosphate, fructose-6-phosphate, ribulose-5-phosphate, and 6-phosphogluconate showed a decreasing trend at low DO levels, potentially favoring flux through the EMP pathway and relieving energy demands for cell metabolism in the presence of higher redox level status at low DO levels.

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Consistent with the results of the DO shift-down experiments in this study, collectively, organic acids (except succinate) showed an increasing trend while sugar phosphates showed a decreasing trend as the DO dropped down ( Figure 7 ).

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