Multi-omics analysis of intra-tumoural and inter-tumoural heterogeneity in pancreatic ductal adenocarcinoma.

Clin Transl Med · 2022 · PMC8782496 · PMID 35061935

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an overall trendno p-value reported

ZNF521 exhibits chromosomal rearrangement or loss in 63% PDAC tumours and an overall trend of reduced expression in PDAC tumours compared with matched normal ductal epithelial cells. 33 Consistently, we found that ZNF521 was lowly expressed in all the samples from tumours P8–P19, except P9–T4, suggesting that low expression of ZNF521 may serve as a biomarker for PDAC.

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