CHK1 inhibition exacerbates replication stress induced by IGF blockade.

Oncogene · 2022 · PMC8782724 · PMID 34773074

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In DNA fiber assays DNA fiber tract shortening was induced by MK-8776 or IGF-1R depletion, the latter effect consistent with Figure 1E , and MK-8776 caused highly significant fiber shortening in IGF-1R depleted cells ( Figure 3A ), indicating extreme replication fork delay.

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