Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance.

Proc Natl Acad Sci U S A · 2022 · PMC8784142 · PMID 35017298

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hedged sentences

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP = 7.75E-08actually significant

Most notable is the association between sEPSC amplitude and WCST in the combined SCZ+CON sample, with a highly significant main effect across groups ( P = 7.75E-08, adjusted R 2 = 0.8947) and interaction of sEPSC amplitude with diagnostic group ( P = 1.23E-08).

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marginally significantP < 0.005actually significant

Gene set enrichment analyses were performed with the clusterProfiler Bioconductor package ( 57 ), using the hypergeometric test to assess enrichment of marginally significant DEGs (at P < 0.005) that were stratified by case–control directionality, against a background of all expressed genes that had Entrez gene IDs.

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