The Potential Prebiotic Berberine Combined With Methimazole Improved the Therapeutic Effect of Graves' Disease Patients Through Regulating the Intestinal Microbiome.

Although methimazole treatment did not significantly change the Shannon or Simpson indexes after 6 months, they both showed a decreasing trend ( Figure 2A ).

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Six months after berberine combined with methimazole treatment, FT4, FT3 and TSH showed significant changes compared to baseline, with FT4, FT3 and TRAb showing a decreasing trend and TSH showing an increasing trend ( Figure 3 ).

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