It will be necessary to acquire detailed and elaborated evidence to reliably assign mechanisms of shape regulation in vivo , including those shape-induced self-immune responses discussed here. Still, practically speaking, our observations of in vivo shape regulation are potentially highly significant, suggesting the possibility of controlling the breaking of balances of immunity and tolerance.
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A Nanoscale Shape-Discovery Framework Supporting Systematic Investigations of Shape-Dependent Biological Effects and Immunomodulation.
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