Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1β-induced osteoarthritis by downregulating the MAPK and NF-κB pathways.

In particular, the levels of TNF-α and IL-6 in the 1000 nM ononin group were reduced 2-fold and 3-fold, respectively, compared with those in the control group; moreover, this downregulation showed a decreasing trend with increasing ononin concentrations.

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