On the other hand, an observed trend for decreasing acetaminophen sulfate levels could be due to altered sulfonation activity caused by impaired sulfur activation in NASH ( Canet et al., 2015 ), which highlights the importance (and challenge) of distinguishing changes in metabolite formation from transporter-mediated alterations.
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The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates.
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The sentences
Species differences in transporter affinity and inhibition potency may be significant when evaluating drug safety.