SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB₁ receptors.

The inverse agonist possibly influences the cognitive aspect of nociception in this test, as the stress of injection might play a role in activating the ECS, an effect that might be significant at early, but not later post‐injection time points (Woodhams et al., 2017 ).

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