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The influence of tumor heterogeneity on sensitivity of EGFR-mutant lung adenocarcinoma cells to EGFR-TKIs.

Transl Cancer Res · 2019 · PMC8797522 · PMID 35116934

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a decreasing trendno p-value reported
However, in the erlotinib+ subgroups of A549/PC-9 or MRC-5/PC-9 co-culture systems, MET amplification showed a decreasing trend.

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an increasing trendno p-value reported
MET amplification of co-cultured PC-9 cells MET amplification exhibited an increasing trend in the erlotinib+ subgroup of the H1975/PC-9 co-culture system with the increasing proportion of upper chamber H1975 cells.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.