highly significantp < 0.001
The contribution of the Arginine pathway was further confirmed by pathway analysis, conducted with Metaboanalyst 27 , which indicated “Arginine biosynthesis” as highly significant (p < 0.001). “Aminoacyl-tRNA metabolism” (p < 0.001), “Histidine metabolism” (p = 0.005), and “Alanine, Aspartate and Glutamate metabolism” (p = 0.026) were also indicated as significant pathways.