Field cancerization profile-based prognosis signatures lead to more robust risk evaluation in hepatocellular carcinoma.

Moreover, the fraction of tumoral dendritic cells component was significantly (highly significant in dendritic cells resting (HR = 0.4 (0.23–0.69), p < 0.001) and marginally significant in dendritic cells activated (HR = 0.56 (0.30–1.04), p value = 0.067)) and positively associated with poor prognosis, suggesting a deleterious effect on clinical outcome, whereas a totally opposite beneficial effect was observed in peritumor samples (dendritic cells resting [HR = 1.97 (1.27–3.06), p value = 0.003]; dendritic cells activated [HR = 2.92 (1.07–7.98), p value = 0.037]) ( Figure 5 B).

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