FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells.

Unexpectedly, a significant upregulation of IL-4, IL-10, and IL-13 transcripts was not observed in the rm-FGF2 treatment group compared with that in the HDM group, although there is an increasing trend (9.49 ± 2.57 vs. 5.58 ± 0.24, 17.12 ± 2.86 vs. 13.5 ± 1.12, and 382.40 ± 55.95 vs. 326.40 ± 39.29 for IL-4, IL-10, and IL-13, respectively, P > 0.05, Fig. 5 d).

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