Blockade of the Notch Signaling Pathway Promotes M2 Macrophage Polarization to Suppress Cardiac Fibrosis Remodeling in Mice With Myocardial Infarction.

Front Cardiovasc Med · 2021 · PMC8801444 · PMID 35111821

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Additionally, further experimentation revealed that treatment with sh-RBP-J also brought about a decrease in collagen content and degree of fibrosis, which is particularly important as macrophages are heralded as highly significant in the process of fibrosis ( 23 ).

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