Transcriptomic and Metabolomic Analyses Reveal Inhibition of Hepatic Adipogenesis and Fat Catabolism in Yak for Adaptation to Forage Shortage During Cold Season.

Importantly, 306 main metabolites (213 up-regulated and 93 down-regulated) were considerably significantly altered from each other, especially under the different seasons (VIP > 1, p <0.05, and FC ≤ 0.67 or ≥1.5; Supplementary File S1 ).

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In addition, compared with the YC group, there was an increasing trend but no significant differences in serum antioxidant index, including T-AOC, GSH-PX, MDA, and SOD in the YW group ( p > 0.05; Table 3 ) Metabolomic Profiling An untargeted metabolomics approach studied the specific impact of seasonal changes in external conditions, especially food availability, and on metabolomic profiling.

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