Synthesis, Characterization, and <i>in vivo</i> Evaluation of a Novel Potent Autotaxin-Inhibitor.

A slight trend to a higher score in the I/R group (1.13 ± 0.13; p = 0.200) compared to controls was also noted ( Figures 9I,J ). 4 Discussion 4.1 Medicinal Chemistry Our initial attempt to find new proprietary ATX-inhibitors was based on the seed compound PF-8380 ( 1 ) and relied on modifications of the molecule which are in essence: 1) the ZBG, 2) the core region, and 3) the structural element that fits into the lipophilic pocket ( Figure 1A ).

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