We compared this to the differences in mean cervical PR-BS methylation between healthy controls and breast cancers from our discovery set cervical samples and observed a substantial skew towards PR-BS sites which are hypomethylated in both cervical and breast tissue in at-risk women with a highly significant overlap of 2,623 hypo-methylated CpGs (defined as a methylation difference < −0.02) in both breast and cervical samples (Fig. 6c ).
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The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.
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