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Association of maternal socioeconomic status and race with risk of congenital heart disease: a population-based retrospective cohort study in Ontario, Canada.

BMJ Open · 2022 · PMC8808396 · PMID 35105571

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a decreasing trendno p-value reported
The proportion of pregnant individuals who used tobacco, social drugs or alcohol during pregnancy also demonstrated a decreasing trend from Q1 to Q5 neighbourhoods by maternal education level.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.