Temporal Expression Pattern of Hemoxygenase-1 Expression and Its Association with Vasospasm and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.

Early HO-1 Induction May Protect Against Development of Vasospasm, Whereas Late HO-1 Expression is Associated with Occurrence of DCI When analyzing patient subgroups, patients that exhibited sonographic vasospasm at any point in time during hospital treatment showed a nonsignificant trend toward lower HO-1 mRNA expression levels on day 7 after SAH than those without sonographic vasospasm [Fig. 6 a, HO-1 mRNA expression level 282.1 (89.15–571.5) vs. 634.8 (224.4–1326) (fold induction vs. control), n = 50, p = 0.059].

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