Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth.

Nat Commun · 2022 · PMC8814139 · PMID 35115535

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highly significantno p-value reported

Analysis of mRNA expression data revealed a highly significant negative correlation between expression levels of GNAI2 (encoding Gαi2) and β-catenin target genes in human colon tissue (Fig. 5a and Supplementary Fig. 10 ), in line with Wnt signaling inhibition by Gαi2 in vivo.

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